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References in periodicals archive ?
Rubraca is an oral, small molecule inhibitor of PARP enzymes, including PARP1, PARP-2, and PARP-3, being developed for the treatment of solid tumors associated with homologous recombination deficiency (HRD), defined as the presence of a deleterious BRCA1 or BRCA2 mutation, a deleterious mutation in another gene involved in DNA damage repair, and/or a high percentage of tumor genome with LOH, a phenotypic consequence of HRD.
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases.
The homologous recombination pathway is complex and involves a number of genes.
In campylobacter, antigenic variation of Surface layer proteins (SLPs) is the result of homologous recombination that leads to its antigenic variation.
In simple eukaryotes, homologous recombination is predominant, while in humans the non-homologous mechanism is better represented.
On the other hand, BRCA1 interacts with RAD51 recombinase (RAD51) during homologous recombination mediated DNA double-strand break repair forming a nucleoprotein filament on DNA and its mutation can increase the risk of breast cancer (9-11).
Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes [XRCC.
Yeast cells are masters of a process called homologous recombination in which bits of matching DNA can swap with one another.
Mario Capecchi to perform the pioneering experiments in the use of homologous recombination to modify genes in mammals.
In fact, inactive rDNA units were associated with condensin, a protein complex that condenses rDNA and connects sister-chromatids for repair by homologous recombination (Fig.
Approximately 90% of NF1 microdeletions (Types-1, -2, and -3) are recurrent and arise via nonallelic homologous recombination between low-copyrepeats (REPs), which are paralogous regions flanking the NF1 gene.
DSBs are repaired by two pathways: the so-called homologous recombination (HR) or non-homologous end-joining (NHEJ) (Figure 12) (Kanaar et al.