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1986) into human equivalent concentrations (HEC) by converting from intermittent exposure to continuous exposure, from shorter to longer duration of exposure, and from rat physiology to human physiology (Supplemental Material available online at http://www. 05]; HEC, human equivalent concentration [the human concentration (for inhalation exposure) of an agent that is believed to induce the same magnitude of toxic effect as the experimental animal species concentration or dose; this adjustment may incorporate toxicokinetic information on the particular agent, if available, or use a default procedure, such as assuming that daily oral doses experienced for a lifetime are proportional to body weight raised to the 0. |
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