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The human artificial chromosome survived for as long as 6 months in cells, retaining its integrity while replicating during many cell divisions, Willard and his team report in the April Nature Genetics. The bovine production system is created by introducing the full, unrearranged sequences for both the human heavy and light chain antibody genes into cows, using a human artificial chromosome (HAC) vector, developed by Hematech's collaborators at the Kirin Brewery Company. The bovine TransChromo system is created by introducing the full, unrearranged sequences for both the human heavy and light chain antibody genes into cows, using a human artificial chromosome (HAC) vector, developed by Hematech's collaborators at the Kirin Brewery Company. |
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