| Acronym | Definition |
|---|
| HCS | Hazard Communication Standard |
| HCS | High Content Screening |
| HCS | Host Computer System |
| HCS | Human Capital Solutions |
| HCS | Human Capital Strategist (certification; Human Capital Institute) |
| HCS | Harvard Computer Society |
| HCS | Hard Clad Silica (optical fiber) |
| HCS | Human Capital Strategy |
| HCS | Histochemical Society |
| HCS | Highway Capacity Software |
| HCS | Human Chorionic Somatomammotropin |
| HCS | High Carbon Steel |
| HCS | Hierarchical Cell Structure |
| HCS | Header Check Sequence (DOCSIS specification) |
| HCS | Healthcare Software (Australia) |
| HCS | Helicopter Combat Support (Special) Squadron (US Navy) |
| HCS | Header Checksum |
| HCS | Hospital & Healthcare Compensation Service |
| HCS | Hajdu-Cheney Syndrome |
| HCS | Halley's Comet Software |
| HCS | High Current System |
| HCS | HUMINT Control System |
| HCS | Human Control Strategy (robotics) |
| HCS | HES Cabling Systems (Turkey) |
| HCS | Hundred Call Seconds |
| hCS | Human Chorionic Somatotropin |
| HCS | Hub City Stompers (New Brunswick, NJ band) |
| HCS | Helicopter Coordination Section |
| HCS | House Connection Sewer |
| HCS | Holland Christian Schools |
| HCS | Hardcore Style (music) |
| HCS | Housing Counseling Services, Inc (Washington, DC) |
| HCS | HardCore Supervisor (Multics) |
| HCS | Health Care Secretary |
| HCS | Home and Community-Based Service Program |
| HCS | High-Performance Computing and Simulation Research Laboratory |
| HCS | Humanitarian Common Service |
| HCS | Helicopter Control Ship |
| HCS | Harrogate Choral Society (UK) |
| HCS | Hybrid Computation and Simulation |
| HCS | Health Card Server |
| HCS | Hydrogen Chloride Scrubber |
| HCS | Healthcare Compensation Solutions (Prattville, AL) |
| HCS | Haptic Characteristic Structures |
| HCS | HAF Computer System |
| HCS | Hydrogen Containing Solvent |
| HCS | Haven City Stories (online RPG) |
| HCS | High Class Society |
| HCS | Hutchinson Computer Systems Ltd (UK) |
| HCS | Human Communications Science |