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Participants in the Hypertension Optimal treatment (HOT) trial (40) with an elevated baseline creatinine level, were two to threefold more likely to experience major or fatal cardiovascular events compared with subjects with lower creatinine levels. Furthermore, according to clinical results from the landmark Hypertension Optimal Treatment (HOT) Study (L. The Hypertension Optimal Treatment trial (9) was intended to show the benefits of aggressive treatment of hypertension and to refine the goal of treatment. |
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