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ICAM-1

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AcronymDefinition
ICAM-1Intracellular Adhesion Molecule One

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Although the specific findings differed among the protocols, all three protocols with exercise showed UFP-associated reductions in expression of adhesion molecules on leukocytes, mainly ICAM-1 (CD54) and the [[beta].
This inhibited recruitment occurs despite the rapid mobilization of surface [beta]2-integrins (CD11b/CD18) and ICAM-1 (CD54), which ordinarily mediate the second phase of tight endothelial-cell binding.
Anti-ICAM-1 antibody has been shown to attenuate damage in the brain, heart, kidney, and other tissues where ICAM-1 plays a critical role in ischemia-induced damage.
 
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