IGF-2

AcronymDefinition
IGF-2Insulin-Like Growth Factor 2
References in periodicals archive ?
We hypothesized that IGF-2 gene was associated with T2DM patients when compared to controls.
There is considerable evidence that IGF-2 regulates cell growth, differentiation, and metabolism.
Previously, it was shown that polymorphisms in the IGF-1 and IGF-2 genes are associated with features of the metabolic syndrome.
The major limitations of this study were small sample size was and only a single single-nucleotide polymorphisms was selected from IGF-2 gene.
The protein molecules of IGF-1 and IGF-2 can be divided to B- (receptor binding domain), C-(determines preferential binding to IGF-R1), A- (in part, receptor binding domain), D- (determines the affinity of IGF-2, but not IGF-1, to receptor binding) and E-domains (Fig.
The gene for IGF-2 is located close to the insulin one, on a chromosome 11p15.
The synthesis of IGF-2 is relatively growth hormone independent.
The biological effects of IGF-1 and IGF-2 on a target cell are mediated by two types of cell surface receptors: IGF receptor of type 1 (IGF-R1) and IGF receptor of type 2 (IGF-R2), as well as through binding to receptors for insulin (Fig.
El IGF-2 actua como un factor de crecimiento autocrino y paracrino, afectando la proliferacion y la diferenciacion de los fibroblastos perivasculares de los grandes vasos sanguineos y capilares de los periocitos (5,12).
Las gonadotropinas maximizan la utilizacion de IGF-1 o de IGF-2 por sus receptores, en el proceso de desarrollo folicular y durante la vida media del cuerpo luteo, ya que incrementan el IGF e inhiben la produccion de IGFBP (30,38,50).
La regulacion de la foliculogenesis es un proceso dinamico, en el cual el IGF-1 y el IGF-2 tienen un importante papel, ya que hay una compleja interrelacion entre FSH, esteroides, factores de crecimiento y otras hormonas que controlan el desarrollo folicular (3,5,6,7,34,43,46,50).
El IGF1 folicular libre, en yeguas, es positivamente correlacionado con los niveles del estradiol, progesterona, androstenediona, IGF-1 e IGF-2 totales (46).