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However IL-15R protein expres-sion was induced while the cells were exposed to IL-15, IL-8, or a combination of IL-1 b and TNF- a.
A Tagl polymorphism in the human interleukin-1 R (IL-1 R) gene correlates with IL-1 R secretion in vitro.
The FDA has granted Orphan Drug status and Fast Track designation to the IL-1 Trap program for the treatment of CAPS.
Because continued exposure to the compound that halted production of IL-1 alpha cannot stave off cell aging and cell death indefinitely, Maciag suggests that the protein may be the first of a repertoire of chemicals that slow endothelial cell growth.
Key objectives of this 1,200 patient study include testing the hypothesis that, in postmenopausal Korean women who are not on hormone replacement therapy, common variations in IL-1 genes are associated with risk of vertebral fractures, as well as low bone mineral density (BMD) and/or elevated markers of bone metabolism.
Everybody's wanted to clone this baby," says Charles Dinarello of Tufts University in Boston, who in 1984 took part in the first cloning of IL-1 itself.
In addition to its immune system functions, IL-1 apparently can induce the pituitary gland to secrete adrenocorticotropic hormone (ACTH) into the bloodstream.
The fast track designation is an important step in the regulatory process for the IL-1 Trap, as we come closer to completing the pivotal study," said George Yancopoulos, M.
At the symposium, Charles Dinarello ofthe Tufts University School of Medicine in Boston described laboratory tests on rabbits that have shown how IL-1 fosters the body's response to trauma or infection by inducing fever, causing inflammation and increasing the need for deep sleep.
Treatment with the IL-1 Trap in the phase 2 study led to immediate and sustained improvements in CAPS patients as assessed by both clinical and laboratory measurements.