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IL1 |
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Binding of IL1 to IL1R2 attenuates IL1-induced inflammatoty responses, such as NF-[kappa]B activation (Dower 2000; Wald et al. Thus, it appears that the signaling pathways involving IL1, TNF, and chemokines activation may be novel targets for V and may play an important role in V-induced acute respiratory syndrome in boilermakers and power plant workers (Levy et al. PCB153 exposure in this study was associated with differential gene expression of proinflammatory cytokines, including IL1, IL2, and the immune response gene MX1. |
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