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IP3RInositol 1,4,5-Trisphosphate Receptor
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The research team, comprising of scientists from Seoul National University, Gyeongsang National University, and Emory University in Atlanta, said that calcium plays a primary role in spreading glioblastoma tumour cells in humans, and that IP3R directly contributes to the amount of calcium released.
They discovered a sub-type of IP3R, or IP3R3, to be very active among brain cancer patients and that caffeine stymies the spread of such compounds, resulting in less tumour growth in the brain and blocks cancer cells from spreading to other parts of the body, reports Xinhua.
Unlike the challenge of pro-amyloid and anti-amyloid theories of AD, Anavex Life Sciences' SIGMACEPTOR(TM) Discovery Platform sigma-1 activator molecules target neuron structures (ER, mitochondrion) with the goal of preventing the neurodegenerative action of the disturbed biochemical pathways and channels (UPR, IP3R, Bcl-2, apoptosis), which recently emerged as putative crucial factors in AD as well as many other neurodegenerative diseases.