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IPSIDImmunoproliferative Small Intestinal Disease
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Considered a variant of MALT lymphoma with nearly complete plasmacytic differentiation, IPSID is a rare disorder.
Just as gastric MALT lymphomas are known to be related to infection with H pylori, IPSID is suspected to result from Campylobacter infection, and early cases have a relatively high rate of response to broad-spectrum antibiotics.
39,61) As opposed to the Western type of lymphoma commonly encountered in Europe and North America, IPSID tends to manifest as malabsorption instead of obstruction, presents in the duodenum or proximal jejunum rather than distal ileum, and exhibits villous atrophy as well as plasma cell infiltration of the adjacent intestine.