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IRF4 |
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ISRE is a key binding site for several TFs, such as IRFs (IRF1, IRF3, IRF4, IRF7, IRF9), STAT1, and STAT2, that regulate IFN-mediated cellular signaling during viral/bacterial infection, cytokine stimulation, and innate immune response (25-27). 6 MUM1/ IRF4 is expressed on B cells with varying numbers of V(H) somatic mutations consistent with cells that are on the verge of exiting or have exited the germinal center and are committed to plasma cell differentiation. The ABC DLBCL signature also included a gene that is translocated in Iymphoid malignancies, IRF4 (MUM1/LSIRF). |
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