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IRF5IFN (Interferon) Regulatory Factor 5
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Blocking the production of IRF5 could help in a range of diseases including RA, lupus and even MS.
Two high-density (43,44) and one low-density GWAS45 in SLE have recently been published, yielding definitive data about several new risk genes, as well as valuable confirmatory data related to several previously identified genes, including STAT4 and IRF5.
The study has suggested that blocking the production of IRF5 in macrophages may help treat autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, lupus, and multiple sclerosis.