IVGTIn Vitro Genetic Toxicity
IVGTIntravenous Glucose Tolerance Test
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As expected higher glucose levels were induced by the IVGT in the GK rat compared to the Wistar rat.
2A no difference in blood glucose responses was seen during the IVGT (IAUG): 416 [+ or -] 43 vs 417 [+ or -] 47 mM x 120 min) irrespective stevioside was administrered or not.
This study shows that stevioside induced a reduction in the blood glucose response to an IVGT in anaesthetized, diabetic GK rats, an increase in the insulin secretion as well as a suppression of the glucagon level.