| Acronym | Definition |
|---|
| IOC | International Olympic Committee |
| IOC | Intergovernmental Oceanographic Commission (UNESCO) |
| IoC | Inversion of Control (OOP pattern) |
| IOC | Input/Output Controller |
| IOC | Initial Operational Capability |
| IOC | Initial Operating Capability |
| IOC | Invasion of Chaos (gaming) |
| IOC | International Oceanographic Commission |
| IOC | Indian Ocean Commission |
| IOC | Immediate or Cancel (trade order) |
| IOC | International Oil Company |
| IOC | Indian Oil Corporation, Ltd |
| IOC | Independent Operating Company |
| IOC | Institute of Organic Chemistry (China) |
| IOC | Industrial Operations Command |
| IOC | Inorganic Chemical |
| IOC | Images-On-Call (teleradiology system) |
| IOC | Information Operations Center |
| IOC | International Ozone Commission |
| IOC | Integrated Oil Company |
| IOC | Integrated Optical Circuit |
| IOC | Intraoperative Cholangiogram |
| IOC | Initial Operational Clearance |
| IOC | Inter-Office Channel |
| IOC | Institute of Carpenters |
| IOC | Inorganic Compound |
| IOC | Interoffice Channel |
| IOC | Index of Cooperation (ITU-T) |
| IOC | Instructor Orientation Course (SCUBA PADI course) |
| IOC | In-Orbit Checkout |
| IOC | Internet Operations Center (IETF) |
| IOC | ISDN Ordering Code (Bellcore) |
| IOC | Infantry Officers' Course (USMC) |
| IOC | Input/Output Cluster (Cray) |
| IOC | Inter Office Communications |
| IOC | Islam on Campus |
| IOC | Independent Operating Carrier |
| IOC | Instantaneous Overcurrent |
| IOC | IOTA Occultation Camera (International Occultation Timing Association) |
| IOC | Interfaith Open Communities |
| IOC | Islamic Observation Centre |
| IOC | Individual Oral Commentary |
| IOC | Information Object Class |
| IOC | INTELSAT Operations Center |
| IOC | Internet Operation Center |
| IOC | Inter-Organizational Coordination |
| IOC | Integrated Optical Component |
| IOC | Intercept Operations Center |
| IOC | Innocent Owner/Operator Certificate |
| IOC | Innovation Ontario Corporation (Government of Ontario Corporation) |
| IOC | Impact Over Cost |
| IOC | In-Orbit Construction (NASA) |
| IOC | In-Organic Chemical |
| IOC | Intrinsic Order Criterion |
| IOC | Involuntary Outpatient Civil commitment |
| IOC | Input Output Cabinet |
| IOC | Intercell Ohmic Contact |
| IOC | International Obesity Congress |
| IOC | Internal Office Communication |
| IOC | Internal Overload Control |
| IOC | Índice de Oscilación Austral (Spanish: Southern Oscillation Index) |
| IOC | Inspector on Call |
| IOC | Internal Office Code |
| IOC | Interactive Orbit Calculator |
| IOC | Inter-Object Concurrency |
| IOC | International Outsourcing Company (Tunisia) |
| IOC | Iraqi Olympic Committee |
| IOC | Indicator of Compromise |
| IOC | Integrated Operations Center (various organizations) |
| IOC | Imitation of Christ |