| Acronym | Definition |
|---|
| ISD | Independent School District |
| ISD | Intermediate School District |
| ISD | Information Services Division |
| ISD | Instructional Systems Design |
| ISD | Information Systems Development |
| ISD | Information Systems Division |
| ISD | Investment Services Directive (Europe) |
| ISD | Information Services Department |
| ISD | Illinois School for the Deaf |
| ISD | Issaquah School District (Washington) |
| ISD | Inspectional Services Department |
| ISD | Integrated Services Digital |
| ISD | Intrinsic Sphincter Deficiency |
| ISD | Internal Security Department (Singapore) |
| ISD | Indiana School for the Deaf |
| ISD | In Service Date |
| ISD | Integrated Service Delivery (American Red Cross) |
| ISD | Instructional System Development (US Air Force Air Education and Training Command AETC AFI) |
| ISD | Inhibited Sexual Desire |
| ISD | In-School Detention |
| ISD | Integrated Systems Development |
| ISD | Iowa School for the Deaf |
| ISD | International Subscriber Dialing |
| ISD | Imperial-class Star Destroyer (Star Wars) |
| ISD | Information System Department |
| ISD | International Society of Differentiation |
| ISD | Imperator-Class Star Destroyer (Star Wars) |
| ISD | Image Section Descriptor |
| ISD | Information Systems Directorate |
| ISD | Independent Sealing Distributors |
| ISD | International School of Dakar (Senegal) |
| ISD | Interim Status Document |
| ISD | Information Storage Device (electronics) |
| ISD | Integrated System Diagnostics, Inc. |
| ISD | Integrated Self-Defense (US DOD) |
| ISD | Institute of Social Development (est. 1991; Sri Lanka) |
| ISD | Implied Standard Deviation |
| ISD | International Standards Development |
| ISD | Interface Summary Design |
| ISD | Incremental Software Development |
| ISD | Immune System Disorder |
| ISD | International Skill Development, Inc. |
| ISD | Image Support Data |
| ISD | Independent Segment Decoding |
| ISD | Ignition Safety Device |
| ISD | Installation Supply Division |
| ISD | Industrie-Sprachen-Dienst (Stuttgart, Germany language courses) |
| ISD | In Striking Distance |
| ISD | Installation Support Division (US Army Corps of Engineers) |
| ISD | India Development Centre |
| ISD | Integrated Services Director |
| ISD | Internal Stability Division (South Africa) |
| ISD | In-flight Service Director |
| ISD | Interim Situation Display |
| ISD | Implementation Support and Development (International Civil Aviation Organization) |
| ISD | Itakura-Saito Distortion |
| ISD | Institut für Statik und Dynamik, Leibniz Universität Hannover |
| ISD | International Systems Development |
| ISD | Intelligent Storage Device (area network environment) |
| ISD | Integrated Solutions Development (Sprint) |
| ISD | Ion Stimulated Desorption |
| ISD | Initial Search Depth |
| ISD | Individual Soldier Detector |
| ISD | Internal Symbol Dictionary |
| ISD | Installation Specific Data |
| ISD | Implantable Stimulation Device (cardiology) |
| ISD | Interference Suppression Devices |
| ISD | Intelligence Support Detachment (USFK specific) |
| ISD | Infrared Suppression Device |
| ISD | Information Systems Designator/Directive |
| ISD | Idle Signal Detected |
| ISD | Instructional Systems Development Design |
| ISD | International Standard Data Network |
| ISD | Incidental Sequences Diagram |
| ISD | Intersite Delivering |
| ISD | Intradiscal Stabilization Device |
| ISD | Integrated Services Document |
| ISD | Intelligence Shared Database |
| ISD | Interface Structure Diagram |
| ISD | International Switched Data |
| ISD | Information System Display |
| ISD | Intersystem Designation |
| ISD | Interoperability and Standardization Director |
| ISD | Islamic Society of Denton (Texas) |
| ISD | Individual Skill Development |
| ISD | Investor-State Dispute (international arbitration) |
| ISD | Insurance Services Division (various organizations) |
| ISD | Intergemeentelijke Sociale Dienst (Dutch: Inter-Municipal Social Services) |
| ISD | Infrastructure Service Delivery |