| Acronym | Definition |
|---|
| ISSC | International Ship Security Certificate |
| ISSC | Interstate Shellfish Sanitation Conference |
| ISSC | Institute for the Study of Social Change (San Francisco, CA) |
| ISSC | International Social Sciences Council |
| ISSC | Integrated Systems Solutions Corporation |
| ISSC | Information Systems Steering Committee |
| ISSC | Information Systems Sub-Committee |
| ISSC | International Seismic Safety Centre (International Atomic Energy Agency) |
| ISSC | Information Systems Support Center |
| ISSC | Information Systems Software Center |
| ISSC | Imposto Sobre Serviços de Comunicações (Portuguese: Communications Services Tax; Brazil) |
| ISSC | Interdisciplinary School of Scientific Computing (University of Pune, India) |
| ISSC | Ivy Singles Social Club |
| ISSC | International Snow Sculpture Championships (Breckenridge, CO) |
| ISSC | International School for Scientific Computing (South Africa) |
| ISSC | In-Service Support Contract (Canada) |
| ISSC | Integrated System Support Concept |
| ISSC | Information Service Support Center |
| ISSC | Information Software Support Center |
| ISSC | Industrial Security Specialist Course |
| ISSC | In-Service Support Center |
| ISSC | Integrated System Support Center |
| ISSC | Interservice Supply Support Committee/Coordinator |
| ISSC | International Softswitch Consortium |
| ISSC | Information Systems Security Center |
| ISSC | International Subcommision on Stratigraphic Classification |
| ISSC | International SKA (Square Kilometre Array) Steering Committee (est. 2000) |