| Acronym | Definition |
|---|
| ISS | International Space Station |
| ISS | Issue |
| ISS | Information Systems Services |
| ISS | Institute for Security Studies |
| ISS | Internet Security Systems, Inc. |
| ISS | Initial (Execution) Sequence Set |
| ISS | Institute for Southern Studies |
| ISS | Islands |
| ISS | Information Systems Security |
| ISS | Istituto Superiore di Sanità (Italian National Institute of Health) |
| ISS | Imaging Science Subsystem (NASA Cassini mission) |
| ISS | Institutional Shareholder Services |
| ISS | Injury Severity Score |
| ISS | Instruction Set Simulator |
| ISS | International Summer School (various locations) |
| ISS | Imposto Sobre Serviços (Brazilian tax) |
| ISS | International Social Service (Switzerland) |
| ISS | Iron and Steel Society |
| ISS | Information Services and Systems |
| ISS | Instituto de Seguros Sociales (Colombia) |
| ISS | Internet Security Scanner |
| ISS | Institute of Social Sciences |
| ISS | Information Security Services |
| ISS | In-Service Support |
| ISS | Inno Setup Script (Windows installer program) |
| ISS | Ion Scattering Spectroscopy |
| ISS | International Skeletal Society |
| ISS | International Society of Surgery |
| ISS | Integrated Systems Solutions |
| ISS | Integrated Service Solutions |
| ISS | Inspection Selection System (roadside inspection software system) |
| ISS | Inside Surface |
| ISS | International Switching Symposium |
| ISS | Imprinted Sportswear Shows |
| ISS | I'm So Sure |
| ISS | Institute of Space Science |
| ISS | Integrated Sounding System |
| ISS | International Shorebird Survey (Manomet Observatory, Manomet, MA) |
| ISS | Information Systems Support, Inc |
| ISS | Integrated Safety System |
| ISS | Integrated Survey System |
| ISS | Internal Security Service (Oman) |
| ISS | Integrated Sensor System |
| ISS | Intelligence Support System |
| ISS | Information Systems Staff |
| ISS | Input Shaft Speed |
| ISS | Inter-Satellite Service |
| ISS | Instructional Systems Specialist |
| ISS | Ion Scattering Spectrometry |
| ISS | Immigrant Services Society of British Columbia (Canada) |
| ISS | Intel Solution Services |
| ISS | Integrated Support System |
| ISS | Instant Start System |
| ISS | International School of Singapore |
| ISS | Integrated Space Systems |
| ISS | Interactive Selling System |
| ISS | Integrated Support Service |
| ISS | Image Stabilization System |
| ISS | International Seismological Summary |
| ISS | Impedance Standard Substrate |
| ISS | Internet Sharing Server |
| ISS | Intelligent Software Solutions, Inc (Raleigh, North Carolina) |
| ISS | Intelligent Sensor Systems (Malardalen University; Sweden) |
| ISS | Instrument Support Structure |
| ISS | Integrated Switching System |
| ISS | Interim Supply Support |
| ISS | International Survivalist Society |
| ISS | Internet Search Service(s) |
| ISS | Isotonic Saline Solution |
| ISS | Institute of Statistical Science |
| ISS | In Stadium Solutions (Coral Springs, FL) |
| ISS | IranskSvenska Solidaritetsföreningen |
| ISS | Immunization Services Support (WHO) |
| ISS | Instructional Support System |
| ISS | Intelligence Support Squadron |
| ISS | Interim Status Standards |
| ISS | Instrument Sales and Service, Inc. |
| ISS | Intelligence Systems Secretariat |
| ISS | Imperial Star Ship (Star Trek) |
| ISS | Intermediate Service School |
| ISS | Isotope Separation System |
| ISS | Information and Systems Society |
| ISS | International Shaw Society (est. 2002) |
| ISS | Information Sharing Session |
| ISS | Insulin Sliding Scale |
| ISS | International Soccer Superstar (video game) |
| ISS | Improved Spread Spectrum (watermarking) |
| ISS | International School Seychelles (Mahé, Seychelles) |
| ISS | Image Server System |
| ISS | Input Sub System |
| ISS | Internal Secondary Structure |
| ISS | Integrated Support Station |
| ISS | Information Systems Squadron |
| ISS | Inertial Survey System |
| ISS | International Sales Support |
| ISS | Institute for State Studies |
| ISS | International Sanitary Systems |
| ISS | Interservice Supply Support |
| ISS | Interactive Support System |
| ISS | Integrated System Support |
| ISS | Image Synthesis Services |
| ISS | Information Superiority and Sensors |
| ISS | Interactive Survivability Simulation |
| ISS | Infrared Surveillance Sensor |
| ISS | Intelligent Server Switch (Apache) |
| ISS | International Supply Services (Portsmouth, VA) |
| ISS | International Scoring Systems (Paris, France) |
| ISS | Integrated SS7 Signaling |
| ISS | InfraStructure Systems GmbH (Hanover, Germany) |
| ISS | Interim Safety Supplement |
| ISS | Integrated Sealift Study |
| ISS | Inventory Support Specialist |
| ISS | Incoming Signal Strength |
| ISS | Integrated Start System |
| ISS | Independent School Services |
| ISS | Institute of Somatic Sciences |
| ISS | IAIPS Support Services |
| ISS | Infinite Server Station |
| ISS | Investment Statistical System |
| ISS | Ingleside State School (Gold Coast, Australia) |
| ISS | Information Sending Service |
| ISS | Infusion Signaling Server |
| ISS | International Settlement System |
| ISS | Internal Secondary Storage |
| ISS | Indirect/Inertial Subsystem |
| ISS | Integrated System Schedule |
| ISS | Initial Shelf Stock |
| ISS | Information Sending Signal |
| ISS | In-School Suspension |
| ISS | International School Sosua (Dominican Republic) |
| ISS | Institutt for Sosiologi og Samfunnsgeografi (Norwegian: Department of Sociology and Human Geography) |
| ISS | Industry Security Services (defense industry, UK) |
| ISS | Institute of Systems Science (National University of Singapore) |