| Acronym | Definition |
|---|
| ISSA | International Social Security Association |
| ISSA | Information Systems Security Association |
| ISSA | International Sports Sciences Association |
| ISSA | International Securities Services Association |
| ISSA | International Slurry Surfacing Association |
| ISSA | International Sanitary Supply Association |
| ISSA | International Ship Suppliers Association |
| ISSA | International Strategic Studies Association |
| ISSA | Interservice Support Agreement |
| ISSA | International Space Station Alpha |
| ISSA | International Step by Step Association (Amsterdam, The Netherlands) |
| ISSA | IRAS Sky Survey Atlas |
| ISSA | International Senior Softball Association |
| ISSA | Information Systems Security Architecture |
| ISSA | International Sociology of Sport Association |
| ISSA | International Society of Securities Administrators |
| ISSA | International Skateboard Slalom Association |
| ISSA | Illini Secular Student Alliance (University of Illinois) |
| ISSA | Inter Scholastic Sailing Association |
| ISSA | Institute for Systems Studies and Analyses (India) |
| ISSA | Irish Student Sport Association |
| ISSA | International Space School Alumni Association |
| ISSA | Installation Supply Support Activity |
| ISSA | Illustrissimus Senatus Studiosorum Amstelodamensium |
| ISSA | Industrial Security Staff Approval (US security clearance) |
| ISSA | Installation Services Support Agreement |
| ISSA | Interservice Supply Support Agreement |
| ISSA | Interim Software Support Activity |
| ISSA | Informationsstelle Südliches Afrika eV |
| ISSA | India Specific Safeguards Agreement (inspections) |