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The results of both in vitro and in vivo studies suggest that elevated levels of endogenous insulin-like growth factor-I (IGF-I), observed during a 2-week endurance training of laboratory animals, increases myocardial expression of IGF-I (Scheinowitz et al. A simple increase in caloric intake above energy requirements enhances growth hormone, testosterone, and insulin-like growth factor-I (IGF-I) concentrations In contrast, energy and protein restriction has produced negative effects on serum IGF-I concentrations, and diets with low percentages of dietary fat are associated with lower testosterone concentrations. The study uses cell cultures and mouse models to look at the physiology of how insulin-like growth factor-I may help increase bone mass and bone growth. |
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