| Acronym | Definition |
|---|
| IOTA | Islands On The Air (ham radio) |
| IOTA | International Occultation Timing Association |
| IOTA | Interest on Trust Accounts |
| IOTA | Infrared Optical Telescope Array |
| IOTA | Institut d'Optique Théorique et Appliquée (French) |
| IOTA | Intra-European Organisation of Tax Administrations |
| IOTA | Institute of Technology Australia |
| IoTA | Institute of Transport Administration |
| iOTA | Internet Over the Air |
| IOTA | Illinois Occupational Therapy Association |
| IOTA | Institute Of Theoretical Astronomy |
| IOTA | Indiana Occupational Therapy Association |
| IOTA | Isle of Thanet Arts (UK) |
| IOTA | Identifiers for Organizations for Telecommunications Addressing (British Standards Institute) |
| IOTA | International Office of Technical Assistance |
| IOTA | Infrastructure Operations Tools Access |
| IOTA | Institute for Oklahoma Technology Applications |
| IOTA | Initiative for the Orderly and Timely Administration of Insolvency Estates (Canada) |
| IOTA | Inbound/Outbound Traffic Analysis |
| IOTA | Illuminates of Thanateros America |
| IOTA | Icons of the Apocalypse |
| IOTA | Interactive Online Tutoring Access |
| IOTA | Institut d'Ophthalmologie Tropical d'Afrique (French) |
| IOTA | Integrated Oceanographic Tactical Aid |
| IOTA | Input Output Transform Architecture |
| IOTA | Interface Océan - Terre - Atmosphère (Centre de Recherches en Physique de l'Environment Terrestre et Planetaire) |
| IOTA | Initial Outfitting of Training Activity |
| IOTA | Input/Output Termination Assembly (Honeywell) |