| Acronym | Definition |
|---|
| ISIS | Intermediate System to Intermediate System |
| ISIS | Intermediate System to Intermediate System (OSI-compliant routing protocol) |
| ISIS | Institute for Software Integrated Systems |
| ISIS | International Study of Infarct Survival |
| ISIS | Image and Scanner Interface Specification |
| ISIS | Institute for Science and International Security |
| ISIS | International Species Information System |
| ISIS | Intelligent Sensing for Innovative Structures (civil engineering) |
| ISIS | Internet Shopping Is Safe |
| ISIS | International Security Information Service |
| ISIS | Integrated Software for Imagers and Spectrometers (planetary mission graphics) |
| ISIS | International Spinal Injection Society (now International Spinal Intervention Society) |
| ISIS | Imaging Science and Information Systems (Center; Department of Radiology, Georgetown University Medical Center) |
| ISIS | Institute for Systems, Informatics, and Safety |
| ISIS | Infinitely Scalable Intelligent Storage |
| ISIS | Industrial Signature Interoperability Specification (Germany) |
| ISIS | International Species Inventory System |
| ISIS | International Society on Infant Studies |
| ISIS | Integrated Standby Instrument System |
| ISIS | International Satellites for Ionospheric Studies |
| ISIS | International Spinal Intervention Society (formerly International Spinal Injection Society) |
| ISIS | Image, Speech, and Intelligent Systems Research Group (University of Southampton) |
| ISIS | Integrated Staff Information System |
| ISIS | Internet Student Information System |
| ISIS | International School of Information Science |
| ISIS | Innovative Systems in Silicon (International Conference) |
| ISIS | Inner Space Interactive Sourcing |
| ISIS | In-situ Storage Image Sensor |
| ISIS | Information Society Initiatives in Standardization (IEEE) |
| ISIS | Image Selected in Vivo Spectroscopy |
| ISIS | Integrated Submarine Imaging System (US Navy) |
| ISIS | Interactive Sound Information System |
| ISIS | Investigative Support Information System |
| ISIS | Interactive Satellite Image Server |
| ISIS | Interactive Sound Integration System (PC multichannel sound board) |
| ISIS | International Superconductivity Industry Summit |
| ISIS | Integriertes Statistisches Informationssystem (Vienna, Austria) |
| ISIS | Implementation of the Single European Sky in South East Europe |
| ISIS | International Splined Interface Standard (bicycle crank and bottom bracket interface) |
| ISIS | Intelligent Searching of Images and Signals |
| ISIS | Iowa Student Information System (University of Iowa) |
| ISIS | Industry Support Information Services |
| ISIS | Isochronal Scheduled Inspection System |
| ISIS | Integrated Security and Identification System |
| ISIS | Independent School Information Service |
| ISIS | Integrated Ship Information System |
| ISIS | Institute for the Study of Interdisciplinary Studies |
| ISIS | Integrated Signals Intelligence System |
| ISIS | Integrated Standards Information System |
| ISIS | Interactive Student Information Service |
| ISIS | Integrated Safeguards Information System |
| ISIS | International Science Information Service |
| ISIS | Italian Silicon Sphere |
| ISIS | Integrated Shipboard Information Systems |
| ISIS | Inflatable Shield in Space |
| ISIS | Information Superhighway in Space |
| ISIS | Images & Scanners Interface Standard |
| ISIS | Integrated Stored Information System |
| ISIS | International Satellite for Ionospheric Study |
| ISIS | Interoperability and Standardization of Information Systems |
| ISIS | Integrated Strike & Interceptor System |
| ISIS | Integrated Systems for Installation Support |
| ISIS | Interactive Scientific Information System |
| ISIS | Interchangeability/Substitutability Information System |
| ISIS | Inspection & Safety Information System |
| ISIS | Information Systems and Infrastructure Services (MITRE) |