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1% reduction in total invasive pneumococcal disease burden was noted in children who received at least one dose of the vaccine. Although the current introduction of conjugate pneumococcal vaccine has successfully reduced invasive pneumococcal disease caused by the vaccine serotypes and effectively decreased the spread of antimicrobial drug-resistant isolates, pneumococcal infection remains a major issue, in light of the selective pressure that has been invoked by vaccination programs (3,4). 17-19) In another 3-year surveillance study of invasive pneumococcal disease, resistance to penicillin increased from 21 to 25% from 1995 to 1998. |
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