| Acronym | Definition |
|---|
| ISC | Internet Storm Center |
| ISC | Internet Software Consortium |
| ISC | Internet Systems Consortium, Inc |
| ISC | International Speedway Corporation |
| ISC | Information Security Conference |
| ISC | IMS (IP Multimedia Subsystem) Service Control |
| ISC | Short Circuit Current (semiconductor device property) |
| ISC | International Sculpture Center (Hamilton, NJ, USA) |
| ISC | International Songwriting Competition |
| ISC | International Steering Committee |
| ISC | Institute for Sustainable Communities |
| ISC | International Security Conference |
| ISC | IP Solution Center (Cisco) |
| ISC | Idle Speed Control |
| ISC | Imperial Sugar Company |
| ISC | International Seismological Centre |
| ISC | Internet Society of China |
| ISC | Interagency Security Committee (EOP) |
| ISC | International Storytelling Center |
| ISC | International Study Center (Boston College) |
| ISC | Industrial Source Complex (model) |
| ISC | International Softball Congress (Farmington, UT) |
| ISC | Institute for Strategy and Competitiveness |
| ISC | Integrated Supply Chain |
| ISC | Internet Scrabble Club (Romania) |
| ISC | International School of Choueifat |
| ISC | Integrated Support Command (USCG) |
| ISC | Impuesto Selectivo al Consumo (Spanish: Selective Consumption Tax) |
| ISC | Institutional Shareholders' Committee |
| ISC | Indian subcontinent (geographic region) |
| ISC | Initiative for Software Choice |
| ISC | International Society of Chemotherapy (for Infection and Cancer; UK) |
| ISC | International Studies Center |
| ISC | Instruction Set Computer |
| ISC | Information Systems Committee |
| ISC | Information Systems Center |
| ISC | Interstate Compact (supervision of offenders, parolees or probationers) |
| ISC | I Stand Corrected |
| ISC | International Softswitch Consortium |
| ISC | International Student Council |
| ISC | Invention Submission Corporation |
| ISC | International Scientific Conference (various locations) |
| ISC | Information Systems Command (US Army) |
| ISC | Information Service Center |
| ISC | Inverse Symbolic Calculator |
| ISC | International Society of Cryptozoology |
| ISC | Istituto Sperimentale per la Cerealicoltura |
| ISC | International Switching Center |
| ISC | Intermittent Self-Catheterisation |
| ISC | Institut de Stratégie Comparée (French: Comparative Strategy Institute) |
| ISC | Imaging Supplies Coalition |
| ISC | Intermittent Self-Catheterization |
| ISC | Information Systems Coordinator |
| ISC | Internet Solutions Company |
| ISC | International Society of Citriculture |
| ISC | International Supreme Council (Order of DeMolay) |
| ISC | Information Systems Company |
| ISC | Intermediate Service Center (Cook County, Illinois schools) |
| ISC | Intelligent System Controller |
| ISC | Isles Of Scilly, Isles Of Scilly, United Kingdom - Tresco (Airport Code) |
| ISC | Infrastructure Subcommittee |
| ISC | Independent Search Consultants |
| ISC | International School of Curacao (Emmastad, Curaçao) |
| ISC | International Study Circle |
| ISC | International Safety Council (UK) |
| ISC | Integrated System Control |
| ISC | Installation Support Center (US DoD) |
| ISC | Independent Service Center |
| ISC | Inpatient and Surgical Care |
| ISC | Integrated Ship Controls |
| ISC | International Sericultural Commission |
| ISC | Input Signal Conditioner |
| ISC | Institutional Shareholder Committee |
| ISC | Information Systems Contract |
| ISC | Integration Support Contract |
| ISC | In-System Configurable |
| ISC | Indian Student Count |
| ISC | Insider Stock Compensation (IRS) |
| ISC | Intelligent Screen Cognition |
| ISC | International Space Corporation |
| ISC | Insurance Support Center (insurance) |
| ISC | Italian Social Club |
| ISC | Informatique-Sciences Cognitives (French: Cognitive Computer Sciences) |
| ISC | International Steering Committee on the Economic Advancement of Rural Women |
| ISC | Intermodal Shipbrokers Co (Athens, Greece) |
| ISC | Idaho Speed Center |
| ISC | International Service Carrier |
| ISC | Integrated Satellite Control |
| ISC | Integrated Site Controller |
| ISC | India Steamship Company |
| ISC | Instrument Support Controller |
| ISC | Icing System Controller |
| ISC | International Sorting Center (USPS) |
| ISC | iLevel Service Center (Weyerhaeuser) |
| ISC | Initial Skills Course |
| ISC | Intermediate Switching Center |
| ISC | Intelligence Subject Code |
| ISC | Intelligence Support Concept |
| ISC | Industrial Support Contractor |
| ISC | Installation Steering Committee |
| ISC | International Signal and Control Corporation |
| ISC | Illinois Symphony Chorus |
| ISC | Instrument Signal Conditioning (NASA) |
| ISC | Intel Support Concept |
| ISC | International Standards Council (International Code Council) |
| ISC | International Society of Chemometrics |
| ISC | Industry Standing Conference |
| ISC | Independent Support Contractor |
| ISC | Installation Status Code |
| ISC | Impact Service Corporation (Spokane, WA) |
| ISC | Intercommunications Set Controller |
| ISC | Initial Safe Concentration |
| ISC | Intercity Service Coordination |
| ISC | Infantry Soldier Computer |
| ISC | Infrastructure Support Contract |
| ISC | Inter Star Connection |
| ISC | Inter/Intraservice Support Coordinator |
| ISC | Interactive Support Capability |
| ISC | International Surveillance and Control (Sprint) |
| ISC | Inter-Software Communications |
| ISC | Indian Space Commission |
| ISC | Intelligent Sprinkler Control (Lake Valley Engineering LLC) |
| ISC | Inspection and Safety Center |
| ISC | Information Technology Systems Coordinator |
| ISC | Indira School of Communications (est. 2004; India) |
| ISC | Intramural Sports Club (various locations) |
| ISC | Institute of Cognitive Science |
| ISC | Integrated Science Center (various schools) |
| ISC | Information Systems Corporation (North Dakota) |
| ISC | International Student Center (various locations) |