To examine if there was evidence of apoptotic cell death in the rat kidney following stress kinase activation by ischemia/reperfusion
, we examined apoptotic cell death in these tissues for TUNEL (TDT-mediated dUTP nick end labeling method).
The company's immune modulation therapy currently targets the following primary medical categories: 1) the treatment of cardiovascular diseases, including peripheral vascular disease (PVD) and congestive heart failure (CHF); 2) the protection of vital organs and tissues against Ischemia/Reperfusion
(I/R) Injury during major vascular surgery; 3) the treatment of autoimmune diseases; and 4) the treatment of chronic lymphocytic leukemia.
These maneuvers, although valuable in preventing excessive blood loss, are invariably complicated by ischemia/reperfusion
(IR) injury, which can reduce the capacity of the liver remnant to maintain adequate postoperative function [4, 5].
Beneficial effect of enteral glycine in intestinal ischemia/reperfusion
In addition to psoriasis treatment, the Company is developing immune modulation therapies for a number of other conditions characterized by immune system dysfunction and inflammation, including peripheral vascular disease, graft-versus-host disease, congestive heart failure, ischemia/reperfusion
injury, and chronic lymphocytic leukemia.
Therefore, on the basis of previous findings, we presumed that parkin and Drp1 would exert neuroprotective effect on cerebral ischemia/reperfusion
that occurred in stroke.
In addition to CLL, Vasogen is advancing the commercial development of immune modulation therapy for the treatment of a number of autoimmune and inflammatory conditions, including psoriasis, peripheral vascular disease, congestive heart failure, ischemia/reperfusion
injury, and graft-versus-host disease.
(IR) injury is still an unsolved problem in the clinical practice, efforts are being made to prevent it; in this regard, Dr.
Recent studies indicate that focal ischemia/reperfusion
(I/R) can cause the contractile dysfunctions induced in animal models of partial bladder outlet obstruction.
Interferon-gamma has been reported to be a mediator of the damage caused to organs by ischemia/reperfusion
injury, and elevated levels of IL-6 have been demonstrated in patients suffering from congestive heart failure.
Hotter, "Actin cytoskeleton derangement induces apoptosis in renal ischemia/reperfusion
," Apoptosis, vol.
In addition to VasoCare(TM) therapy for the treatment of peripheral vascular disease, the Company is developing immune modulation therapies for a number of additional autoimmune and inflammatory conditions, including psoriasis, graft-versus-host disease, congestive heart failure, and ischemia/reperfusion