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JAK2 |
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Cytopia is continuing to build on its range of JAK inhibitors and kinase expertise, with CYT387, a novel oral JAK2 inhibitor focused on the treatment of myeloproliferative disorders, expected to enter Phase I clinical studies in early 2009. 31 Identifying a V617F mutation in the JAK2 gene by molecular study on peripheral blood and/ or bone marrow is very helpful in confirming a diagnosis of MPD; this mutation is present in almost all cases of polycythemia vera and in about 50% of cases of essential thrombocythemia and chronic idiopathic myelofibrosis. It hits an enzyme called JAK2 that is linked to several diseases. |
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