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PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in maerophages. He added that "Kinexus is routinely tracking over 1000 phosphorylation sites with its proteomics screening services, and it has already identified the JNK and p38 MAPK protein kinases as drug targets using the Kinetworks(TM) method. Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apeptesis. |
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