Most JSLE patients have musculoskeletal involvement, mainly arthritis, arthralgia, or tenosynovitis.
The characteristic neurologic manifestations of JSLE are seizures and psychosis, but a host of additional signs and symptoms may occur.
Anemia, thrombocytopenia, and leukopenia are seen in 50-75% of JSLE.
Lower frequencies of renal involvement in children with JSLE were reported in western countries.
In the past, renal disease was the major cause of mortality in patients with JSLE, but with earlier diagnosis and newer methods of treatment, the outlook for patients with lupus nephritis has vastly improved.