KCC2 - What does KCC2 stand for? The Free Dictionary
References in periodicals archive
BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2
The discovery of the complex of three proteins is pathbreaking as it was previously believed that KCC2
and GluK2 were in separate compartments of the cell and acted independently of each other.
Cohen, will investigate whether supplying KCC2
directly to the dentate gyrus will restore normal functioning in that structure, and whether it may improve symptoms in brain-injured mice.
Exposing neurons to minute amounts of BPA alters the chloride levels inside the cells by somehow shutting down the Kcc2 gene, which makes the KCC2
protein, thereby delaying the removal of chloride from neurons.
By restoring normal KCC2
activity we could potentially prevent pain hypersensitivity.
They removed KCC2
altogether from damaged cells and found they died.