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References in periodicals archive ?
In the present work it is shown that phosphorylation of kainate receptors on its own promotes their activity.
81) KYNA is a tryptophan metabolite that has selective activity against NMDA, quisqualate, and kainate receptors in the central nervous system.
Thirteen chapters deal with N-methyl-n-aspartate (NMDA) receptors, 8 with 2-amino-3-hydroxy-5-methyl-4-isoxazole propicnic acid (AMPA) receptors, 6 with kainate receptors, and 6 with metabotropic receptors.
It disrupts normal neurochemical transmission in the brain by binding to certain glutamate receptors, the so-called kainate receptors, of neuronal cells.
Pipeline candidates fall under major therapeutic classes such as NSAIDs, opioid receptors, AMPA and kainate sub-type receptors, kappa opioid receptors, conopeptide analogs, TRPV1 antagonists, Imidazoline I2 binding receptors, platelet glycoprotein IIb/IIIa receptors, Mu-opioid receptors, and ligand activated therapy.
DP-b99 was neuroprotective against kainate induced neuronal loss and prevented MMP-9-mediated dendritic spine transformation.
AMPA and kainate are the ones that work quickly, while NMDA can lead to changes in plasticity over time.
Soman induces ictogenesis in the amygdala and interictal activity in the hippocampus that are blocked by a GluR5 kainate receptor antagonist in vitro.
The neurotransmitter glutamate interacts with several receptors, including the A-methyl-D-aspartate (NMDA), [alpha]-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate, and metabotropic glutamate receptors.
BDNF enables the release of glutamate by prohibiting the function of kainate receptors, which slow down the development of the preforms of the synapses.
6) Topiramate potentiates [gamma]-aminobutyric acid (GABA) activity thus increasing inhibitory neurotransmission, modulates voltage dependent sodium conduction to block sustained, repetitive firing of action potentials and blocks kainate evoked currents via an antagonistic effect on the AMPA pathway but not the N-methyl-D-aspartate (NMDA) pathway.
Kainate induces AKT, ERK and cdk5/GSK3beta pathway deregulation, phosphorylates tau protein in mouse hippocampus.