Anaphore's novel Atrimer[TM] drug candidates are engineered from a fully-human serum protein that is naturally secreted as a trimeric structure of approximately 60 kilodaltons
and designed to have biological, manufacturing and commercial advantages over traditional drugs.
It is a complex polysaccharide fiber of repeating galacturonic acid groups with neutral sugar side chains, modified using a specific enzymatic process to a molecular weight of 3 to 15 kilodaltons
, a degree of esterification under 10%, and a specific structure.
The researchers used the instrument to test a sample of the protein bovine serum albumin (BSA), which is known to have a mass of 66 kilodaltons
Nucleotide sequence comparison of haemolysin encoding hlyA gene from classical and El Tor strains reveal the presence of an 11 base-pair deletion in classical strains that results in a truncated protein product of 27 kilodaltons
in classical strains rendering it non haemolytic, whereas in El Tor strains the HlyA is intact 82 kilodalton
and biologically active (12).
Since the average molecular weight of an amino acid is 118 daltons, multiplication by 210 produces an unglycosylated protein of about 25 kilodaltons
To understand how the site of pegylation and the size of the PEG molecule affect antiviral specific activity, researchers at Schering-Plough Research Institute prepared for biological analysis purified positional pegylation isomers of interferon alfa-2b pegylated at various sites with PEG polymers ranging from 5 to 30 kilodaltons
(kD) in size.
A family of surface-exposed proteins of 20 kilodaltons
in the genus Borrelia.
They have molecular weights ranging from about 2 to 100 kilodaltons
and a well defined geometry in water solution, particularly in the region surrounding the active site.
Our novel Atrimer[TM] drug candidates are engineered from a fully human serum protein that is naturally secreted as a trimeric structure of approximately 60 kilodaltons
vWF circulates in plasma as multimers, ranging in size from 500 to 20,000 kilodaltons
Researchers have also identified a more potent form of RNase L in CFS patients that is less than half the normal molecular weight of 80 kilodaltons
For example, in Figure 7, the E1250X mutation changes a glutamic acid to a stop signal and produces a truncated protein of approximately 62 kilodaltons