Rapamycin could reduce 24-h urinary protein levels in the PI and EP subgroups of L-NA and LPS, but had no effect on the MAP of L-NA and LPS preeclampsia-like mouse models [Figure 1].
In the PI and EP subgroups of the L-NA group, hepatocyte ballooning degeneration and loose tissue structure could be observed.
It was found that rapamycin had no significant effect on the blood pressure of preeclampsia-like mouse models, but it could significantly reduce 24-h urinary protein in PI and EP subgroups of L-NA and LPS groups.
To determine the nature and the source of ROS, sections were incubated with either, superoxide dismutase (500 Mimi), MnTMPyP (membrane-permeant super-oxide dismutase mimetic, 100 [micro]M), polyethylene glycol-catalase (membrane-permeant analog of catalase, 500 Ul/m1), catalase (500 Ul/ml), L-NA (NO synthase inhibitor, 300 [micro]M), indomethacin (cyclooxygenase inhibitor, 10 ELM) for 30 min at 37[degrees]C before addition of dihydroethidine.
L-NA, indomethacin, ACh, PE, sodium nitroprusside, levcromakalim were obtained from Sigma-Aldrich.
Inhibitors of NO synthesis MK-801, AP5 Gold fish Learning of avoidance task MK-801 Mice Learning of avoidance task L-NAME Rats Learning and memory of maze performance Rabbit Eye-blink conditioning Chicks Learning of avoidance task Rats Learning and memory of avoidance task Rats Learning of avoidance task Octopus vulgaris Learning of avoidance task Aplysia Learning of avoidance task Honey bee Learning of olfactory discrimination L-NA
Rats Learning and memory of avoidance task Rats Learning and memory of maze performance Rats Learning and memory of maze performance L-NMMA Rats Memory of avoidance task 7-NI Rats Learning and memory of avoidance task Rats Learning and memory of maze performance Chicks Learning of avoidance task 4.
50] = 25 [micro]M) and L-NA
, a NO synthase inhibitor ([IC.