nitro-L-arginine methyl ester (L-NAME
) is an endothelial nitric oxide synthase inhibitor, and our previous study showed that injecting L-NAME
intoC56BL/6J mice could induce preeclampsia-like symptoms such as hypertension and proteinuria, as well as long-chain fatty acid oxidation (FAO) disorders.
Results: [DELTA]MAP with both doses of L-NAME
5] M L-NAME
, a direct inhibitor of NO synthase; iii) [10.
9% NaCl, 5 ml/100 g) to impose a controlled water and salt load, different groups of rats received L-NAME
(60 mg/kg, given 1 h before the experiments; p.
Accordingly, the pre-treatment with L-NAME
(nitric oxide synthase inhibitor) reduced EP-Mt leukocyte migration by 38% (5.
A traditional approach to evaluate coupled Ach-dilation is by the use of blocking agents that inhibit NOS, decreasing NO production, such as L-NAME
or others (Buxton et al.
Therefore, the aim of the present study was to evaluate the in vivo histological dental pulp state after indirect pulp capping using sildenafil or L-NAME
, both incorporated into a new BTS.
05: compared with SAH rats pretreatment with MLB and L-NAME
For identifying eNOS as a source of superoxide, aortic rings were incubated in L-NAME
(500 [micro]M) for 30 mins at 37[degrees]C before freezing for cryosectioning as previously described .
The rats in the L-NAME
group were treated with L-NAME
(Cayman Chemical Company, Ann Arbor, MI, USA; 1 mg/mL) in their drinking water for 8 weeks (the water was replaced daily).
in combination with DECC did not change the negative inotropy, negative chronotropy and the decrease in coronary flow induced by DECC.
Se uso el modelo de hipertension por L-NAME
, teniendo en cuenta lo realizado por Sanchez-Mendoza y col (15), con modificacion del animal experimental y el sensor para raton, que es usado ampliamente para estudiar la fisiopatologia de la hipertension arterial (16).