L-NAMEG -nitro-L-Arginine-Methyl Ester
L-NAMEL-Nitro-Arginine Methyl Ester
L-NAMEN-Nitro-L-Arginine Methyl Ester
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nitro-L-arginine methyl ester (L-NAME) is an endothelial nitric oxide synthase inhibitor, and our previous study showed that injecting L-NAME intoC56BL/6J mice could induce preeclampsia-like symptoms such as hypertension and proteinuria, as well as long-chain fatty acid oxidation (FAO) disorders.
9% NaCl, 5 ml/100 g) to impose a controlled water and salt load, different groups of rats received L-NAME (60 mg/kg, given 1 h before the experiments; p.
A traditional approach to evaluate coupled Ach-dilation is by the use of blocking agents that inhibit NOS, decreasing NO production, such as L-NAME or others (Buxton et al.
For identifying eNOS as a source of superoxide, aortic rings were incubated in L-NAME (500 [micro]M) for 30 mins at 37[degrees]C before freezing for cryosectioning as previously described [21].
The rats in the L-NAME group were treated with L-NAME (Cayman Chemical Company, Ann Arbor, MI, USA; 1 mg/mL) in their drinking water for 8 weeks (the water was replaced daily).
L-NAME in combination with DECC did not change the negative inotropy, negative chronotropy and the decrease in coronary flow induced by DECC.
Se uso el modelo de hipertension por L-NAME, teniendo en cuenta lo realizado por Sanchez-Mendoza y col (15), con modificacion del animal experimental y el sensor para raton, que es usado ampliamente para estudiar la fisiopatologia de la hipertension arterial (16).