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LANP |
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Of the transcriptional regulators ataxin-1 interacts with LANP is the one predominantly expressed in Purkinje cells-the cells primarily affected in SCA1. Vie are currently studying one such protein--the leucine-rich acidic nuclear protein (LANP) that stands as a compelling mediator of mutant ataxin-1 toxicity: LANP was picked up in a genome-wide screen for identifying proteins that bind ataxin-1; indeed LANP has a greater affinity for mutant ataxin-1 than wild type ataxin-1. Based on our preliminary results, we hypothesize that LANP plays a role in SCA1 pathogenesis by serving as a mediator of toxicity in SCA1. |
LANP |
lano- LANOIA LANOK lanolin lanolin lanolin lanolin bush lanolin bush lanolin bush lanoline lanoline lanoline LANOMS Lanophyllin Lanophyllin Lanophyllin Lanos lanose lanosity Lanosterol Lanosterol lanoteplase Lanoux, Armand Lanovtsy Lanoxicaps Lanoxicaps Lanoxicaps Lanoxin Lanoxin Lanoxin LANP LANPAGLanparty Lanparty LANR LANRC LANREMT Lanreotide LANRover Lans Lans Lans Lans lansa lansa LANSAD lansan lansat Lansbury Lansbury Lansbury, George LANSC LANSCE LANSCE/Energy Research Program LANSD Lansdale Lansdale Catholic Lansdale Presbyterian Church Lansdale, Pennsylvania Lansdown Lansdown | |||||
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