No statistically significant difference was observed between the FLC values for samples stored at the three temperatures for 1 week when compared with the fresh or 1-day-old samples (KFLC and LFLC in fresh samples vs samples stored at 2-8 [degrees]C for 1 week, P <0.
5% for KFLC, LFLC, and K/L FLC ratio in 8 of 10 individuals.
In a group of 13 patients with acute or chronic renal failure of various etiologies, including secondary amyloidosis, and end-stage renal failure on hemodialysis, FLC concentrations were increased in all patients, but the K/L FLC ratio was within the population reference interval (KFLC, 45-166 mg/L; LFLC, 32-347 mg/L; K/L ratio, 0.
In eight patients with stable disease and intact serum immunoglobulin (2-19 g/L) or trace urine BJP, the KFLC concentration was 4-30 mg/L, the LFLC concentration was 9-40 mg/L, and the K/L ratio was 0.
In a group of 32 MGUS patients (10 males, 40-73 years of age, 0-17 years since diagnosis; 22 females, 45-79 years of age, 0-22 years since diagnosis) with a current serum Mprotein concentration of 1-22 g/L and clinically stable disease, the KFLC concentration was 7-1018 mg/L, the LFLC concentration was 9-211 mg/L, and the K/L ratio ranged from 0.
3) Nonstandard abbreviations: NSM, nonsecretory myeloma; AL amyloidosis, primary amyloidosis; FLC, free light chain; BJP, Bence Jones protein; PBSCT, peripheral blood stem cell transplantation; KFLC, [kappa] free light chain; LFLC, [lambda] free light chain; K/L FLC ratio, [kappa]/[lambda] free light chain ratio; M-protein, monoclonal protein; MM, multiple myeloma; and MGUS, monoclonal gammopathy of undetermined significance.