Additionally, it can be speculated that such changes induced by LNAME
treatment are partially associated with reduced SIRT1 protein expression.
Loss of calbindin D28k positive neurons in CA1/2 regions were also observed in 7NI and LNAME
treated animals indicating neuronal damage in the hippocampus.
In summary, the polyphenols found in the extract Murtilla could stimulate the activation of eNOS-NO-GCs pathway, as the vasodilator effects were partially reversed by LNAME
4], acido ascorbico, clorhidrato de fenilefrina, cloruro de acetilcolina, indometacina, LNAME
, dimetilsulfoxido, clorhidrato de propranolol y sulfato de atropina (Merck[R]).
pretreatment, which inhibited NO-dependent relaxation, inhibited relaxation more strongly in Epi-treated rats as compared to controls (Figure 4(e)).