LRP5

AcronymDefinition
LRP5Low Density Lipoprotein Receptor-Related Protein 5
References in periodicals archive ?
To date, the alliance with Wyeth has been successful, marked by the discovery of LRP5, publication of the research in the American Journal of Human Genetics, validation of LRP5's role in bone biology by other research groups, confirmation by Wyeth in pre-clinical models and the advancement of the research program into screening," said Steven M.
Researchers were able to identify a single amino acid change in the LRP5 protein receptor responsible for above average bone mineral density.
The LRP5 gene research conducted by our team illustrates the importance and potential impact this mutation will have in addressing a growing international health concern," said Robert R.
The etiology of low bone mass in these patients was attributed to the following: idiopathic osteoporosis (n = 6); familial osteoporosis (n = 4); glucocorticoid use (n = 3); loss-of-function mutations in the LRP5 (low-density lipoprotein receptor-related protein 5) gene (heterozygous, n = 2; homozygous, n = 1); postmenopausal osteoporosis (n = 2); juvenile Paget disease (n = 2); postpregnancy osteoporosis (n = 2); and anorexia, hypophosphatasia, and depot medroxyprogesterone use (n = 1 each).
Sclerostin, the protein product of SOST, is a circulating inhibitor of the Wnt-signaling pathway that achieves this by binding to LRP5 and LRP6 (56).
Identifying the molecules that bind to LRP5 is a high priority, he and Cohn agree.
Gerard Karsenty of the Baylor College of Medicine in Houston and his colleagues created mice with mutations in their LRP5 genes and found that the rodents developed osteoporosis and eye abnormalities.
Variants in the LRP5 gene are associated with both bone mineral density and fracture risk, researchers reported in JAMA.
Two LRP5 variants were found to have "modest" effects that were very consistent across different populations and independent of subject sex or age.
In osteoporosis, Raptor is testing the ability of WntTide(TM), which are Mesd and engineered Mesd-based peptides and act through LRP5, a known determinant of bone density, to combat osteoporosis and increase bone density.
In osteoporosis, Raptor is testing the ability of WntTide, which are Mesd and engineered Mesd-based peptides and act through LRP5, a known determinant of bone density, to combat osteoporosis and increase bone density.