LTD4

AcronymDefinition
LTD4Leukotriene D4 (lipid mediator)
References in periodicals archive ?
Mk is a selective antagonist of the LTD4 receptor, a pathway shown to play minor role gouty arthritis (26, 27), Therefore, it is possible that LTD4 may have a heretofore unknown role in acute gouty arthritis.
It inhibits the binding of three leukotrienes (LTC4, LTD4 and LTE4) that are responsible for smooth muscle constriction and hyperresponsiveness after contact with an allergen challenge including exercise (Krawiec & Wenzel, 1999).
It limits 5-1ipoxygenase pathway activation limiting the production of LTA4, LTC4, and the derivatives of cysteinyl LT, LTD4, and LTE4, which are potent vasoconstrictors (Balzano, Fuschillo, & Gaudiosi, 2002).
Montelukast inhibits physiologic actions of LTD4 at the CysLT1 receptor without any agonist activity.
Montelukast causes inhibition of airway cysteinyl leukotriene receptors as demonstrated by the ability to inhibit bronchoconstriction due to inhaled LTD4 in asthmatics.
MK-0476, an LTD4 receptor antagonist, improves the signs and symptoms of asthma with a dose as low as 10mg once daily [abstract].
Zafirlukast and pranlukast are both orally active antagonists of LTD4 and represent the furthest advanced of all the anti-leukotriene drugs currently being developed.
Sisteinil lokotrienler (LTC4, LTD4, LTE4) ve LTB4 RSV enfeksiyonlu cocuklarda ve fare orneklerinde defalarca nazofaringeal ve trakeobronsiyal salgi larda saptanmislardir (48).
Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) play a major role in broncho-constriction, mucus production, airway edema, and inflammation, all factors that contribute to asthma symptoms.
Tender notice number : BR AHMEDABAD MCB ACC SEEMA JEWELRS P LTD4