LTE4Leukotriene E4 (lipid mediator)
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The products of the 5-1ipoxygenase pathway include the leukotrienes LTC4, LTD4, and LTE4, which are potent inflammatory mediators that can act to (1) induce mucus secretion, bronchoconstriction of the airway, and edema of the nasal mucosa and (2) attract eosinophils into the airways.
Secondary outcome measures will include a self-administered Asthma Quality of Life Questionnaire, the change from baseline in morning and evening peak flow rates, rescue beta-agonist use, serial spirometry parameters including assessment of acute effects following first dose on Day 1, daytime asthma symptom scores, nighttime awakenings from asthma, physician's global assessment, number of asthma exacerbations, discontinuations due to asthma, Clinical Global Impression evaluations and change in urinary LTE4 levels.