There was also an increase in posti schemic recovery of LVDP at 40 min after reperfusion in the multipollutant-mixture group compared with the FA control group (70.
The decreased LVDP and cardiac contractility, delayed ischemic contracture, and preserved contractility during reperfusion consequent to exposure to inhaled multipollutant mixtures could indicate altered intracellular [Ca.
Heart rate (A) and LVDP (6) at baseline prior to ischemia in murine hearts isolated 8-11 hr after inhalation exposure to filtered air (FA), multipollutant mixtures (mixtures), or [O.
max], heart rate and coronary flow when given alone or together with DECC Drug LVDP
(mmHg) Control 30 minutes DECC 118.
Pretreatment with wine 12% or 6% improved LVDP function after reperfusion (Table 1) compared with control hearts (p<0.
Haemodynamic parameters of perfused rat hearts Reperfusion Pre-ischaemic 5 min LVDP (mmHg) Control 87 [+ or -] 1 16 [+ or -] 2 Wine 6% 87 [+ or -] 2 27 [+ or -] 5 * Wine 12% 88 [+ or -] 3 26 [+ or -] 3 * Alcohol 6% 87 [+ or -] 5 12 [+ or -] 2 Alcohol 12% 87 [+ or -] 6 10 [+ or -] 4 Heart rate (bts/min) Control 340 [+ or -] 17 192 [+ or -] 32 Wine 6% 307 [+ or -] 13 260 [+ or -] 34 Wine 12% 300 [+ or -] 9 250 [+ or -] 37 Alcohol 6% 304 [+ or -] 10 228 [+ or -] 27 Alcohol 12% 328 [+ or -] 15 232 [+ or -] 66 Flow (ml/min) Control 13.
The observed cardiac function changes included decreased LVDP
and [+ or -] dP/dt.
The CF and LVDP were continuously monitored during the perfusion of modified Krebs buffer in COC extract-treated heart and I/R heart.
In the present study, administration of COC extract improved the cardiac contractility and left ventricular function, as evidenced by the increase in CF and LVDP.
Abbreviations: COC, Crataegus oxycantha; I/R, Ischemia/reperfusion; OPC, Oligomeric proanthocyanidin; ROS, Reactive oxygen species; LVDP, Left ventricular developed pressure; CF, Coronary flow; HR, Heart rate; RPP, Rate pressure product; LDH, Lactate dehydrogenase; CK, Creatine kinase; TTC, Triphenyltetrazolium chloride
After ischemia reperfusion, the FR ultra-fine group showed significantly lower recovery of postischemic LVDP
(Figure 6A) and increased infarct size (Figure 6B) compared with the saline controls.