Caption: Unpublished results of one study hint that lamotrigine
might be effective for children with bipolar depression.
(level 2) (primarily for BD II patients)
From December 1994, when lamotrigine
was approved, through November 2009, 40 cases of aseptic meningitis in pediatric and adult patients taking the drug were reported to the FDA, with symptoms starting within 1-42 days of treatment initiation (mean of 16 days).
is a fairly new anticonvulsant, which was FDA-approved for the treatment of seizures in 1994, and for treatment of bipolar disorder in 2003.
doses and the side-effect profile are also discussed.
The National Institute of Clinical Excellence (Nice) said drugs including gabapentin, lamotrigine
and levetiracetam were recommended for the management of epilepsy in people who had not benefited from older drugs.
Newer anticonvulsant medications, including lamotrigine
and gabapentin, are being studied to determine their efficacy as mood stabilizers in manic-depressive disorder.
Use of lamotrigine
has remained steady and continues to compete within the antiepileptic drug class, as physicians perceive the drug to be one of the safest among the mood stabilizers and antipsychotics, despite the risk of a rare, life-threatening rash.
The acquisition includes one product marketed under an Abbreviated New Drug Application (ANDA) - Ursodiol tablet - and one approved ANDA that is not yet marketed - Lamotrigine
orally disintegrating tablet (ODT).
At this point, I confirmed the diagnosis as bipolar disorder and had her agree to take lamotrigine
Adjusted mean IQs were 105 for carba-mazepine, 108 for lamotrigine
, and 106 for phenytoin, compared with 99 in the children of mothers who took valproate.
The link between anticonvulsant agents and suicidal acts or violent death--first revealed in a Food and Drug Administration meta-analysis in 2008--appears to have been confirmed for four of the drugs: gabapentin, lamotrigine
, oxcarbazepine, and tiagabine, investigators reported.