| Acronym | Definition |
|---|
| LSO | Lesotho (ISO Country code) |
| LSO | Laser Safety Officer |
| LSO | Landing Signal Officer |
| LSO | Large Send Offload |
| LSO | Lutetium Oxyorthosilicate (chemistry) |
| LSO | Longwood Symphony Orchestra (Brookline, MA) |
| LSO | Lone Star Overnight (Austin, TX) |
| LSO | Local Shared Objects (web browsers) |
| LSO | Learning Support Organization |
| LSO | Landing Safety Officer |
| LSO | Legal Services Office (Montana) |
| LSO | Legal Support Organization |
| LSO | Left Salpingo-Oophorectomy |
| LSO | Lifestyles Organization |
| LSO | Liberty Symphony Orchestra (Liberty, MO) |
| LSO | Linux Standards Organization |
| LSO | Lansdowne Symphony Orchestra (Lansdowne, PA) |
| LSO | Littleton Symphony Orchestra (Littleton, CO) |
| LSO | Leveraged Sell-Out |
| LSO | Logistics Support Officer |
| LSO | Lovaniensis Scientificus Ordo (Louvain-la-Neuve, Belgium) |
| LSO | Local Switching Office |
| LSO | Legislative Service Organization |
| LSO | cerium doped lutetium orthosilicate |
| LSO | Lawson Smart Office |
| LSO | Labor Standards Officer |
| LSO | Local Servicing Office |
| LSO | Linked Simulation-Optimization |
| LSO | Limited Service Offering |
| LSO | Large-Scale Offensive (aggressive strategy) |
| LSO | Local Service Organization |
| LSO | Large Scale Organization |
| LSO | Linguistic Sign-Off |
| LSO | Life Support Officer |
| LSO | Landward Security Officer |
| LSO | LAN Systems Organization (Intel) |
| LSO | Licensed Security Officer |
| LSO | List of Stored Options |
| LSO | Lanarkshire Society of Organists (UK) |
| LSO | Ladies Social Outreach |
| LSO | Latent Semantic Optimization (computing) |
| LSO | Lumbar Sacral Orthosis |
| LSO | London Symphony Orchestra |
| LSO | Lead Service Office |
| LSO | Laser Squad Orlando (Florida) |