| Acronym | Definition |
|---|
| LES | Lesbian |
| LES | Lower East Side (Manhattan) |
| LES | Large Eddy Simulation |
| LES | Leave and Earnings Statement |
| LES | Licensing Executives Society (USA & Canada) |
| LES | Lower Esophageal Sphincter |
| LES | Laser Eye Surgery |
| LES | Lupus Eritematoso Sistemico (Italian) |
| LES | Law Enforcement Sources |
| LES | Living Earth Simulator (research project) |
| LES | LAN Emulation Server (ATMF) |
| LES | Lake Effect Snow |
| LES | Line Errored Seconds |
| LES | Land Earth Station (INMARSAT) |
| LES | Logistics Execution System |
| LES | Launch Escape System |
| LES | Locally Engaged Staff |
| LES | Law Enforcement Sensitive (security classification) |
| LES | Linear Expenditure System |
| LES | Locally Employed Staff |
| LES | Lambert-Eaton Syndrome |
| LES | Leading Edge Services |
| LES | Luxembourg Employment Study |
| LES | Lincoln Experimental Satellite |
| LES | Loop Emulation Service |
| LES | LAN Extension Service |
| LES | Locally-Enhanced Sampling |
| LES | Lakeshore Engineering Services (Detroit, MI) |
| LES | Learning and Evaluation Situation (psychology) |
| LES | Waste Management Laboratory |
| LES | Low Energy System |
| LES | Laidlaw Environmental Services, Inc |
| LES | Local Education Service |
| LES | Local Engineering Specification |
| LES | Launch Environment Simulator |
| LES | Life Enhancement Skills (UK FE students) |
| LES | Local Excitatory State |
| LES | Laser Evaluator System |
| LES | Laboratorio de Energie Solar |
| LES | Launch Effort Simulator |
| LES | Launch Enable System (Titan II) |
| LES | Law Enforcement Squadron |
| LES | Large Extension Switch |
| LES | Lawrence Experimental Station |
| LES | Loral Electronics Systems |
| LES | Launch Enable Switch (US Navy) |
| LES | Loop Expert Systems (Loop Expert Technologies) |
| LES | Loaded Equipment Section |
| LES | Local Exported Schema |
| LES | Laser and Enterprise Business Solutions (Hewlett-Packard) |
| LES | Liquid Effluent Services (Office of Scientific and Technical Information; US Department of Energy) |
| LES | Lutheran Elementary School (various locations) |
| LES | Lower Eastern Shore (region) |