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1) At that time, histiocytosis X was subdivided into three types: (1) eosinophilic granuloma, an isolated osteolytic lesion: (2) Hand-Schuller-Christian disease, a multifocal version of eosinophilic granuloma that is often accompanied by systemic manifestations; and (3) Letterer-Siwe disease, a systemic, rapidly progressive form of histiocytosis X. |
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