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LTB4Leukotriene B4
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The meta-analysis uncovered a significant association between omega-3 supplementation in reduction in thromboxane B2 in the blood of participants at high risk of cardiovascular disease and in leukotriene B4 in the neutrophils of unhealthy subjects.
Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis: the role of leukotriene B4.
Target: exclusive license to technology for targeting effects of leukotriene B4 (LTB4)
Geha and his colleagues wondered whether the production of leukotriene B4 served to recruit T cells to the site of mechanical insult.
Inhibition of TNF-[alpha], interleukin-6, leukotriene B4, TPA-induced edema and carrageenan-induced oedema has been shown in mice.
There were no differences in laboratory values, including levels of histamine and leukotriene B4 that could be attributed to either of the drugs.
Defective metabolism of leukotriene B4 in the Sjogren-Larsson syndrome.
Two omega-3 fatty acids in fish oil, eicosapentaenoic acid and docosahexaenoic acid, exert anti-inflammatory effects by competitively inhibiting conversion of arachidonic acid to the proinflammatory eicosanoids prostaglandin E2 and leukotriene B4.
CTX-4430 works by inhibiting Leukotriene A4 hydrolase (LTA4H), the major rate-limiting step in Leukotriene B4 (LTB4) production.
18-23) In addition to 5-HETE, 5-LOX also metabolizes arachidonic acid to leukotriene B4 and other pro-inflammatory agents that promote cancer.
Many inflammatory mediators are implicated, including leukotriene B4 and PGE2, which amplify the inflammatory response, induce apoptosis and lead to further tissue damage.