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Pleskow WW, Nelson HS, Schaefer K, Claus R, Roach JM: Pairwise comparison of levalbuterol versus racemic albuterol in the treatment of moderate-to severe asthma.
Previous data have shown BIS to be stable chemically and compatible physically when administered simultaneously with respiratory medications, including albuterol sulfate inhalation solution (Proventil[R]; Schering Corporation, Kenilworth, NJ), ipratropium bromide inhalation solution (Atrovent[R]; Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT), and levalbuterol inhalation solution.
XOPENEX(R) brand levalbuterol HCl Inhalation Solution - Marketed through Sepracor's sales force, XOPENEX Inhalation Solution is a short-acting bronchodilator indicated for the treatment or prevention of bronchospasm in patients 6 years of age and older with reversible obstructive airway disease, such as asthma.
For bronchodilation and quick relief of symptoms using a nebulizer, both Albuterol and Levalbuterol (Xopenex, Sepracor) are available.
Levalbuterol (Xopenex), containing only the therapeutically active R-isomer of albuterol, is available in a nebulizer solution; an inhalation aerosol in a metered-dose inhaler, formulated with a nonchlorofluorocarbon propellant called hydrofluoroalkane (HFA), was approved in March but is not expected to be available until the end of this year.
Drazen's effusive praise for Sepracor's drug levalbuterol, which he was paid to evaluate, was featured in company advertising materials and was later criticized as overstated by the FDA.
Levalbuterol, which consists of only the active R-enantiomer, is also available and is theoretically more effective with fewer adverse effects.
Short-acting agents include albuterol, levalbuterol, and pirbuterol, although these agents at one time were considered longer acting in comparison with the ultrashort-acting catecholamines such as isoetharine.
Short-acting bronchodilators include albuterol (Vospire), levalbuterol (Xopenex), and ipratropium (Atrovent).
Reddy's unveils US FDA approved Levalbuterol Inhalation Solution, USP for oral inhalation only