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However, the role of tumour suppressor gene mutations is indicated by their association with Li-Fraumeni syndrome, which is characterized by inactivating germline mutations of the TP53 gene, gives some insight into the origins of these tumours (1, 3). TP53 Mutations in the TP53 gene on 17p are also known to predispose to early breast cancer [23] and account for over 70% of cases of Li-Fraumeni syndrome [24]. Genetics Childhood osteosarcoma is often more prevalent in children with certain rare cancer syndromes that are inherited - such as retinoblastoma or Li-Fraumeni syndrome. |
Li-Fraumeni syndrome |
Li Ye Li Yongshun Li Yu Li Yü Li Yu (disambiguation) Li yuan Li yüan Li Yuan-Hung Li Yüan-hung Li Yuanhong Li Zhen fan Li Zhèn fán Li Zhen-fan Li Zhenfan Li Zhènfán Li Zhizao Li Zicheng Li Zongren Li'l Abner Li'l Miss Muffet LI-BIRD LI-DCA Li-fo Li-fo Li-fo Li-fo Li-Fraumeni cancer syndrome Li-Fraumeni syndrome Li-ionLi-liger Li-lo Li-lo Li-los Li-los LI-MASC Li-on Li-tigon Li-tigon LI/I LI/LO LI/O LI1 Li18nux Li2 Li20 LI3 LIA LIA LIAA LIAAC LIAB LIABDA Liabiba Faizovna Ikhsanova Liabiba Ikhsanova liabilities liabilities liabilities liabilities | |||||
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