| Acronym | Definition |
|---|
| LSC | La Salle College |
| LSC | La Salle College (Hong Kong) |
| LSC | La Serena, Chile - La Florida (Airport Code) |
| LSC | Lambda Switch Capable |
| LSC | LAN Software Contract |
| LSC | Large Scale Computer |
| LSC | Large Solar Concentrator |
| LSC | Larson Salvage Company (Bay City, Michigan) |
| LSC | Laser Scanning Microscope |
| LSC | Latin School of Chicago |
| LSC | Launch Sequence Control |
| LSC | Lead System Command |
| LSC | Learning and Skills Council |
| LSC | Learning Skills Council |
| LSC | Learning Strategies Consortium |
| LSC | Least Significant Character |
| LSC | Least Squares Circle (shape testing) |
| LSC | Lecture Series Committee |
| LSC | Legal Services Commission (UK) |
| LSC | Legal Services Corporation |
| LSC | Liberty Science Center (Jersey City, New Jersey) |
| LSC | Library Society of China |
| LSC | Life Safety Code |
| LSC | Life Sciences Center |
| LSC | Life Support Center |
| LSC | Lifestyle Shopping Center |
| LSC | Lightguide Shelf Combination (AT&T) |
| LSC | Lighting Sub Circuit |
| LSC | Lightning Strike Coalition (Transformers comics) |
| LSC | LIGO Scientific Collaboration |
| LSC | Line Scan Camera |
| LSC | Line Side Connection |
| LSC | Line Signaling Channel (ITU-T) |
| LSC | Linear Shape Charge |
| LSC | Link State Control (CCS #7/ITU-T) |
| LSC | Liquid Scintillation |
| LSC | Liquid Scintillation Counter |
| LSC | Liteon Semiconductor Corporation |
| LSC | Live Sequence Chart (sequence diagram UML) |
| LSC | Load Sharing Control |
| LSC | Loading Standardization Crew |
| LSC | Local School Council |
| LSC | Local Swimming Committee |
| LSC | Logistics Section Chief |
| LSC | Logistics Steering Committee (US military) |
| LSC | Logistics Support Center |
| LSC | Logistics Support Charge |
| LSC | Logistics Support Concept |
| LSC | Logistics Support Cost |
| LSC | London Seed Capital Limited (London, UK) |
| LSC | Longshore Current |
| LSC | Loop Start Card |
| LSC | Loopback Select Code (Hekimian) |
| LSC | Lyndon State College (Lyndonville, VT) |
| LSC | Lab for Scientific Computing |
| LSC | Label Switch Controller |
| LSC | Lattice Semiconductor Corporation |
| LSC | Lightweight Stream Control Protocol |
| LSC | Limited Slip Coupling |
| LSC | Local Service Centre |
| LSC | Local Support Center |
| LSC | Long String in Context |
| LSC | Luxury Sport Coupe |
| LSC | Luxury Sport Cruiser |
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