| Acronym | Definition |
|---|
| LSC | Learning and Skills Council (UK) |
| LSC | Legal Services Commission (UK) |
| LSC | Legal Services Corporation |
| LSC | Local School Council |
| LSC | Learning Skills Council |
| LSC | Lake Superior College (Duluth, MN) |
| LSC | Liberty Science Center (Jersey City, New Jersey) |
| LSC | Lyndon State College (Lyndonville, VT) |
| LSC | Life Safety Code |
| LSC | LIGO Scientific Collaboration |
| LSC | Liquid Scintillation |
| LSC | Lambda Switch Capable |
| LSC | Liquid Scintillation Counter |
| LSC | Lecture Series Committee |
| LSC | Local Strategic Partnership |
| LSC | La Salle College |
| LSC | La Salle College (Hong Kong) |
| LSC | Local Swimming Committee |
| LSC | Life Sciences Center |
| LSC | Logistics Section Chief |
| LSC | Least Significant Change (bone density) |
| LSC | Least Significant Character |
| LSC | Laser Scanning Microscope |
| LSC | Logistics Support Center |
| LSC | Live Sequence Chart (sequence diagram UML) |
| LSC | Local Supercluster (astronomy) |
| LSC | La Serena, Chile - La Florida (Airport Code) |
| LSC | Line Scan Camera |
| LSC | Large Scale Computer |
| LSC | Link State Control (CCS #7/ITU-T) |
| LSC | Latin School of Chicago |
| LSC | Licensed School Counselor (designation) |
| LSC | Loop Start Card |
| LSC | Library Society of China |
| LSC | Least Squares Circle (shape testing) |
| LSC | Logistics Support Charge |
| LSC | Lifestyle Shopping Center |
| LSC | Life Support Center |
| LSC | Lightning Strike Coalition (Transformers comics) |
| LSC | London Seed Capital Limited (London, UK) |
| LSC | Linear Shape Charge |
| LSC | Logistics Support Cost |
| LSC | Lower Semi-Continuous Function (mathematical analysis) |
| LSC | Learning Strategies Consortium |
| LSC | Laptop Service Center (various companies) |
| LSC | Loading Standardization Crew |
| LSC | Load Sharing Control |
| LSC | Loopback Select Code (Hekimian) |
| LSC | Line Signaling Channel (ITU-T) |
| LSC | Launch Sequence Control |
| LSC | Lead System Command |
| LSC | Logistics Steering Committee (US military) |
| LSC | Larson Salvage Company (Bay City, Michigan) |
| LSC | Lightguide Shelf Combination (AT&T) |
| LSC | Lighting Sub Circuit |
| LSC | LAN Software Contract |
| LSC | Longshore Current |
| LSC | Lexical Conceptual Structure (linguistics) |
| LSC | Land Surveying Certificate |
| LSC | Liteon Semiconductor Corporation |
| LSC | Line Side Connection |
| LSC | Little Sisters of Christ |
| LSC | Logistics Support Concept |
| LSC | Large Solar Concentrator |
| LSC | Line Side Converter |
| LSC | Lake Superior Consulting, LLC (est. 2002; Duluth, MN) |
| LSC | Lumbermen's Service Corporation (Austin, TX) |
| LSC | Loire et Sillon Cyclisme (French cycling club) |
| LSC | Lafayette School Corporation (Indiana) |
| LSC | Light Switch Cover |
| LSC | Large-Scale Commercial |
| LSC | Lean Supply Chain |
| LSC | Leukemia Stem Cell |
| LSC | Lichen Simplex Chronicus (dermatology) |
| LSC | Large-Scale Change |
| LSC | Logistics and Supply Chain |
| LSC | Large Scale Configuration |
| LSC | Life Skills Coach |
| LSC | Large-Scale Circulation (physics) |
| LSC | Lone Star Conference (athletics; various locations) |