| Acronym | Definition |
|---|
| LIS | Library and Information Science |
| LIS | Location Information Server |
| LIS | Low Income Subsidy (Centers for Medicare and Medicaid Services) |
| LIS | Legislative Information System (Virginia General Assembly) |
| LIS | Laboratory Information System |
| LIS | Long Island Sound |
| LIS | Lost in Space |
| LIS | Learning and Information Services (University of Hertfordshire, UK) |
| LIS | Luxembourg Income Study |
| LIS | Locked-in Syndrome (medical disorder) |
| LIS | Land Information System |
| LIS | Landesinstitut für Schule (German: National Institute for School; Bremen, Germany) |
| LIS | Lingua Italiana Dei Segni (Italian) |
| LIS | Logistics Information System |
| LIS | Laboratory of Intelligent Systems |
| LIS | Lightning Imaging Sensor |
| LIS | Library and Information Service |
| LIS | Logical IP Subnetwork |
| LIS | Line in the Sand |
| LIS | Library Information System |
| LIS | Lissencephaly |
| LIS | Library Information Systems |
| LIS | Liability Insurance Supplement |
| LIS | Landmine Impact Survey |
| LIS | Legume Information System (National Center for Genome Resources and the USDA Agricultural Research Service) |
| LIS | Laser Isotope Separation |
| LIS | Local Installation Source (computer files) |
| LIS | Loan Insurance Scheme (Singapore) |
| LIS | Life Is Peachy (Korn album) |
| LIS | Legislative Information Systems (Columbus, Ohio) |
| LIS | Location Information System |
| LIS | Lines In Service |
| LIS | Local Innovation Systems (MIT Industrial Performance Center project) |
| LIS | Laughing In Silence |
| LIS | Landscape Industry Show |
| LIS | License Information System |
| LIS | Livestock Identification Services Ltd. (Alberta, Canada) |
| LIS | Lesbians in Science |
| LIS | Lisbon, Portugal - Lisboa (Airport Code) |
| LIS | Lotgenoten Incest Slachtoffers (Dutch website) |
| LIS | Local Interconnection Service |
| LIS | Late-onset Idiopathic Scoliosis |
| LIS | Lenders Interactive Services |
| LIS | Laboratorio de Ingenieria Sismica (Spanish: Earthquake Engineering Laboratory; University of Costa Rica) |
| LIS | Liquid Injectable Silicone |
| LIS | Life Imaging Services (Reinach, Switzerland) |
| LIS | Land Information Search |
| LIS | Loyola Institute for Spirituality |
| LIS | Landscape Institute Scotland (UK) |
| Lis | Library of Iterative Solvers for Linear Systems |
| LIS | Load Isolation System |
| LIS | Luftfahrt-Informatik-Service (German: Aviation-Informatics-Services) |
| LIS | Linear Ion Source |
| LIS | Legacy Information System |
| LIS | Linux Integration Service |
| LIS | Libyan Intelligence Service |
| LIS | Lead-In Systems |
| LIS | Leveraged Internet Services |
| LIS | Life Insurance Solution |
| LIS | Logistics and Inventory System |
| LIS | Laser Ignition System |
| LIS | List Insertion Sort |
| LIS | Leasing Information Services (Surry Hills, NSW, Australia) |
| LIS | Law in the Internet Society (Columbia Law School course) |
| LIS | Lithium Ion Storage |
| LIS | Low Intermittent Suction |
| LIS | Link Interface Shelf |
| LIS | Lethality Test System |
| LIS | Laboratoria in Situ |
| LIS | Line Item Summary |
| LIS | Lawful Interception Solutions |
| LIS | Liquid Injectable Silicon |
| LIS | Legislative Institution Strengthening |
| LIS | Linear Interference Suppression |
| LIS | Launch Instant Selector |
| LIS | Local Interstellar Space |
| LIS | Libyan Internet Society |
| LIS | Leven Is Strijd (Dutch: Life Is Struggle) |
| LIS | Load Interrupter Switch |
| LIS | Lipoxygenase Inhibitor Screening |
| LIS | Logicomm Internet Solutions |
| LIS | Loss Input Signal (telcom) |
| LIS | Loss Information System (insurance) |
| LIS | Laboratoire des Images et des Signaux (French) |
| LIS | Life Insurance Settlement |